tar dna-binding protein 43 in neurodegenerative disease

The TAR DNA-binding protein-43 (TDP-43) is a highly conserved 414 amino acid protein with an apparent molecular weight of approximately 43 kDa. TDP-43 was initially identified by localization within the nucleus and its ability to bind the HIV-1 TAR DNA element and in this role may act as a transcriptional repressor ( Ou et al. , 1995 ).

Inclusions of pathogenic deposits containing TAR DNA-binding protein 43 (TDP-43) are evident in the brain and spinal cord of patients that present across a spectrum of neurodegenerative diseases. For instance, the majority of patients with sporadic amyotrophic lateral sclerosis (up to 97%) and a substantial proportion of patients with frontotemporal lobar degeneration (~45%)

CiteSeerX - Scientific documents that cite the following paper: Aulas A, Destroismaisons L, Pickles S, Beleac E, Camu W, Rouleau GA, Vande Velde C: TAR DNA-binding protein 43 (TDP-43) regulates stress granule dynamics via differential regulation of G3BP and TIA-1. Human Mol Genet

TAR-DNA-binding protein 43 (TDP-43) has been identified as a major disease protein in the pathologic lesions in frontotemporal lobar degeneration with 

TAR DNA-binding protein 43 (TDP-43) is an RNA/DNA-binding protein involved in RNA regulation and diseases. In 2006, TDP-43 inclusions were found in the disease lesions of several neurodegenerative diseases. It is the pathological hallmark in both amyotrophic lateral sclerosis and frontotemporal lobar dementia.

Summary: Defects in the RNA-binding protein, TDP-43, are known to cause a variety of neurodegenerative diseases, including amyotrophic lateral 

Request PDF | TAR-DNA binding protein 43 in pick disease | Pick disease (PiD) is a frontotemporal dementia characterized by frontal and temporal atrophy, neuronal loss, gliosis, ballooned neurons

3/16 · TDP-43 was first identified in a screen for protein factors that were capable of binding the long terminal repeat transactive response element of HIV-1. 24 Subsequent studies

The TARDBP gene provides instructions for making a protein called transactive response DNA binding protein 43 kDa (TDP-43).

2022/5/5 · Objective Blood-based biomarkers provide a crucial information in progress of neurodegenerative diseases with minimally invasive sampling method. Validated blood-based biomarker application in people with amyotrophic lateral sclerosis would derive numerous benefits. Canine degenerative myelopathy is a naturally occurring animal disease model to

TAR DNA-binding protein 43 (TDP-43) is a highly conserved nuclear RNA/DNA-binding protein involved in the regulation of RNA processing.