tdp-43 pathology

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08/01/  · TDP-43 pathology causes the cytoplasmic aggregation and mislocalization of Nups and TFs, NPCs are multiprotein channels that act as gatekeepers regulating the receptor

Dr. Donna S Urstadt is a Pathology Specialist in Hillsboro, Oregon. She graduated with honors in 1984. Having more than 38 years of diverse experiences, especially in PATHOLOGY, Dr. Donna S Urstadt affiliates with Tuality Community Hospital, cooperates with many other doctors and specialists in medical group Washington County Pathologists Pc.

In 2006, the 43 kDa transactive response DNA-binding protein (TDP-43) was identified as the major pathological protein in most cases of ALS and 

Abstract. C9ORF72 and the 43 kDa TAR DNA-binding protein (TDP-43) are key mole- cules in the development of TDP-43 pathology in amyotrophic lateral 

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However, the mechanism of TDP-43 pathology in neurodegeneration resulting from repeated head trauma is unknown. We previously demonstrated that 

CBD patients had TDP-43 pathology, while less than 6% of PSP or MSA patients had TDP-43 pathology [10, 116, 164, 168, 169]. An in vivo study using transgenic mice expressing hu-man TDP-43 mutants found that administration of an autophagy-inducing drug could ameliorate TDP-43 pathology in the brain and spinal cord of the transgenic animals [171].

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Transactive response DNA binding protein of 43 kDa (TDP-43) is an intranuclear protein encoded by the TARDBP gene that is involved in RNA splicing, trafficking, stabilization, and thus, the regulation of gene expression.

In turn, this stray TDP-43 waylays the nuclear import protein karyopherin-α and worsens DPR deposition, kicking off a cycle of pathology. "DPR accumulation is the first hit, and TDP-43 the second," Hirth told Alzforum. "Together they initiate a deadly cascade that plugs up the nucleocytoplasmic transport machinery, causing a feedback loop."